House begins a detox program at Mayfield Psychiatric Hospital to get the vicodin out of his system in an attempt to control his hallucinations. House being House, he tries to fool the doctors by not taking his medicine pretending he is getting better, but soon realizes that he has deep underlying issues. He starts his treatment and plans to leave the facility once he is clean, but he is strong-armed into staying by his attending physician, Dr. Darryl Nolan (Andre Braugher). Dr. Nolan agrees to write a recommendation to reinstate House's medical license only if House agrees to further treatment. When House is moved to a new ward in the hospital, he develops a close relationship with his new roommate, Alvie (Lin-Manuel Miranda), and Lydia (Franka Potente), a frequent visitor who helps House bend the rules. House asks Alvie to help him uncover incriminating information about Dr. Nolan that would allow him to blackmail his way out of the treatment center and convinces Lydia to loan him her car to sneak out a delusional patient in an attempt by House to undermine Dr. Nolan's course of treatment. But when devastating events ensue, House is humbled into reluctantly accepting help. The only two main characters that appear in this episode are House and Wilson.